5-Thiometaescaline · 3-Ethoxy-4-methoxy-5-methylthiophenethylamine
#165 5-TME SYNTHESIS: A solution of 10.4 g of 3-bromo-N-cyclohexyl-4-methoxy-5-ethoxybenzylidenimine (see under for its preparation) in 150 mL anhydrous Et2O in a He atmosphere was cooled with an external dry ice acetone bath to -80 °C with good stirring. The addition of 52 mL 1.6 M butyllithium in hexane produced a thick precipitate which was stirred for 5 min. There was then added 8.5 mL of dimethyl disulfide and the reaction mixture gradually became thinner and lighter. The dry ice bath was removed and the reaction allowed to come to room temperature over the course of 15 min. This was then added to 400 mL of dilute HCl. The two phases were separated, and the aqueous phase was heated on the steam bath for 1 h which generated a separate yellow oily phase. On cooling, this set to a yellow solid, which was removed by filtration, washed with H2O, and sucked relatively free of H2O. These yellow solids weighed 14.4 g and were ground under 20 mL of cold cyclohexane which removed almost all the color and, after filtering and air drying, there remained 12.9 g of an off-white crystalline solid that melted at 83–84 °C. Recrystallization from cyclohexane produced 3-ethoxy-4-methoxy-5-(methylthio)benzaldehyde as a white fluffy crystalline material with a melting point of 84–85 °C. Anal. (C11H14O3S) C,H.
To a solution of 8.0 g 3-ethoxy-4-methoxy-5-(methylthio)benzaldehyde in 100 mL nitromethane, there was added 0.5 g anhydrous ammonium acetate and the mixture was heated on the steam bath for 1.5 h, at which time most of the aldehyde had disappeared and there was a sizeable quantity of nitrostyrene as well as a cascade of wrong things down to the origin, as seen by TLC on silica gel, with CH2Cl2. The excess nitromethane was removed under vacuum, and the residual red oil was dissolved in 25 mL of hot MeOH and decanted from a small amount of insoluble material. With cooling in an ice bath for 20 min, bright yellow crystals were formed which were removed by filtration, washed with MeOH and air dried, producing 4.1 g which melted at 80–82 °C. This sample, on resolidification and remelting, melted at 109–110 °C. This higher-melting polymorphic form was also produced by recrystallization of the product from cyclohexane. The two polymorphs were chromatographically and analytically identical. Anal. (C12H15NO4S) C,H.
AH was prepared in the usual manner from a suspension of 3.0 g LAH in 100 mL anhydrous THF, cooled to 0 °C, well stirred in an inert atmosphere of He, and treated with 2.0 mL of 100% H2SO4 added dropwise. There was then added a solution of 2.4 g 3-ethoxy-4-methoxy-5-methylthio-β-nitrostyrene in 20 mL anhydrous THF. The reaction was exothermic, and had come nearly to a boil at the half-addition point. The reaction was cooled again to 0 °C and the remaining nitrostyrene then added. This was brought to a reflux briefly on the steam bath, then cooled again and stirred for an additional 1 h. IPA was carefully added to decompose the excess hydride followed by sufficient 10% NaOH to convert the aluminum oxide to a white, easily filterable mass. This was filtered, the filter cake washed with additional IPA, and the filtrate and washes combined and the solvent removed under vacuum. This was dissolved in 100 mL of dilute H2SO4, which was washed with 2×50 mL CH2Cl2. The aqueous phase was made basic with sodium hydroxide, extracted with 2×50 mL CH2Cl2, and the extracts pooled, dried over anhydrous K2CO3, and stripped of solvent under vacuum to yield a nearly colorless residue. This was distilled at 125–135 °C at 0.3 mm/Hg producing 2.0 g of a water-white oil. This was dissolved in 8 mL IPA, neutralized with 23 drops of concentrated HCl and, with good stirring, diluted with 20 mL anhydrous Et2O. The product 3-ethoxy-4-methoxy-5-methylthiophenethylamine hydrochloride (5-TME) was removed by filtration, washed with Et2O, and air dried to provide a white solid that weighed 2.0 g and melted at 168–169 °C. Anal. (C12H20ClNO2S) C,H.
DOSAGE: greater than 200 mg.
DURATION: unknown.
QUALITATIVE COMMENTS: (with 200 mg) “There was a noticeable tinnitus, but then that comes and goes at odd times without any reason needed. There was perhaps a brush of light-headedness at the third hour point, but other than that, nothing. No effect that can be ascribed to today’s drug trial.”
EXTENSIONS AND COMMENTARY: Nothing comes to mind. This, along with most of the di- and triethylated thiomescaline analogues, represents a lot of synthetic effort without useful qualitative data. If there is any activity, it would only be seen with monster dosages, and why put the body through such potential impact?
11 August 2018 · Creative Commons BY-NC-SA ·

About PiHKAL · info

This version of Book II of PiHKAL is based on the Erowid online version, originally transcribed by Simson Garfinkle and converted into HTML by Lamont Granquist. I drew also on “Tyrone Slothrop’s” (Unfinished) Review of PIHKAL to enumerate the many analogues mentioned in PiHKAL but not described at length. Many, many others have since been added.
I have tried here to expunge any artifacts introduced by the earlier transcriptions and restore the typographic niceties found in the printed edition. I’ve also made minor changes to some chemical names in line with current nomenclature practice. Typically the change is little more than expanding a prefix or setting it in italics. The history page has further details.

Cautionary note

“At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings.
“No one who is lacking legal authorization should attempt the synthesis of any of the compounds described in these files, with the intent to give them to man. To do so is to risk legal action which might lead to the tragic ruination of a life. It should also be noted that any person anywhere who experiments on himself, or on another human being, with any of the drugs described herein, without being familiar with that drug’s action and aware of the physical and/or mental disturbance or harm it might cause, is acting irresponsibly and immorally, whether or not he is doing so within the bounds of the law.”
Alexander T. Shulgin

Copyright notice

The copyright for Book I of PiHKAL has been reserved in all forms and it may not be distributed. Book II of PiHKAL may be distributed for non-commercial reproduction provided that the introductory information, copyright notice, cautionary notice and ordering information remain attached.

Ordering information

PiHKAL is the extraordinary record of the authors’ years exploring the chemistry and transformational power of phenethylamines. This book belongs in the library of anyone seeking a rational, enlightened and candid perspective on psychedelic drugs.
Though Sasha and Ann have put Book II of PiHKAL in the public domain, available to anyone, I strongly encourage you to buy a copy. We owe them — and there’s still nothing quite like holding a real book in your hands.
PiHKAL (ISBN 0-9630096-0-5) is available for US$24.50 (plus $10 domestic first-class shipping) from Transform Press.
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