3-Methoxy-4,5-ethylenedioxyamphetamine
#120 MEDA SYNTHESIS: To a solution of 50 g 3,4-dihydroxy-5-methoxybenzaldehyde in 100 mL distilled acetone there was added 70 g ethylene bromide and 58 g finely powdered anhydrous K2CO3. The mixture was held at reflux for 5 days. This was then poured into 1.5 L H2O and extracted with 4×100 mL CH2Cl2. Removal of the solvent from the pooled extracts gave a residue which was distilled at 19 mm/Hg. Several of the fractions taken in the 203–210 °C range spontaneously crystallized, and they were pooled to give 18.3 g of 3-methoxy-4,5-ethylenedioxybenzaldehyde as white solids with a mp of 80–81 °C. A small sample with an equal weight of malononitrile in EtOH treated with a few drops of triethylamine gave 3-methoxy-4,5-ethylenedioxybenzalmalononitrile as pale yellow crystals from EtOH with a mp of 153–154 °C.
A solution of 1.50 g 3-methoxy-4,5-ethylenedioxybenzaldehyde in 6 mL acetic acid was treated with 1 mL nitroethane and 0.50 g anhydrous ammonium acetate, and held on the steam bath for 1.5 h. To the cooled mixture H2O was cautiously added until the first permanent turbidity was observed, and once crystallization had set in, more H2O was added at a rate that would allow the generation of additional crystals. When there was a residual turbidity from additional H2O, the addition was stopped, and the beaker held at ice temperature for several h. The product was removed by filtration and washed with a little 50% acetic acid, providing 0.93 g 1-(3-methoxy-4,5-ethylenedioxyphenyl)-2-nitropropene as dull yellow crystals with a mp of 116–119 °C. Recrystallization of an analytical sample from MeOH gave a mp of 119–121 °C.
A stirred suspension of 6.8 g LAH in 500 mL anhydrous Et2O under an inert atmosphere was brought up to a gentle reflux. A total of 9.4 g 1-(3-methoxy-4,5-ethylenedioxyphenyl)-2-nitropropene in warm Et2O was added over the course of 0.5 h. Refluxing was maintained for 6 h, and then the reaction mixture was cooled and the excess hydride destroyed by the cautious addition of 400 mL 1.5 N H2SO4. The two clear phases were separated, and the aqueous phase was brought to pH of 6 by the addition of a saturated Na2CO3 solution. This was filtered free of a small amount of insolubles, and the clear filtrate was heated to 80 °C. To this there was added a solution of 9.2 g picric acid (90% material) in 100 mL boiling EtOH, and the clear mixture allowed to cool in an ice bath. Scratching generated yellow crystals of the picrate salt. This salt was filtered free of the aqueous environment, treated with 50 mL of 5% NaOH, and stirred until the picric acid was totally in the form of the soluble sodium salt. This was then extracted with 3×100 mL CH2Cl2, the extracts pooled, and the solvent removed under vacuum. The residue weighed 6.0 g, and was dissolved in 100 mL anhydrous Et2O, and saturated with dry HCl gas. The white solids that formed were filtered free of the Et2O, and ground up under 50 mL of slightly moist acetone, providing 4.92 g of 3-methoxy-4,5-ethylenedioxyamphetamine hydrochloride monohydrate (MEDA) as white crystals.
DOSAGE: greater than 200 mg.
DURATION: unknown.
EXTENSIONS AND COMMENTARY: There are times when the Gods smile in unexpectedly nice ways. Having found the activity of , the “scientific” thing to do would be to compare it against the other “psychotomimetic” amphetamine that was known at that time (this was 1962), namely . Comparing their structures, the only difference of any kind was that two of the adjacent methoxyl groups of TMA were replaced with a 5-membered ring, called the methylenedioxy ring.
Where does one go next? Some perverse inspiration suggested increasing the size of this ring to a 6-membered ring, the ethylenedioxy (or dioxene) homologue. Well, if you thought that getting myristicinaldehyde was a difficulty, it was nothing compared to getting this 6-membered counterpart. But I huffed and I puffed, and I did make enough to taste and to evaluate. And it was here that I got the divine message! No activity!! So, rather than being condemned forever a la Sisyphus to push ever larger rings up my psyche, I gave myself permission to pursue another path. The message was: “Don’t change the groups. Leave them as they are, but relocate them instead.” And that led directly to and its story.
A couple of diversions may be mentioned here. Before the blessed inactivity of MEDA was established, the 7-membered ring counterpart, 3-methoxy-4,5-trimethylenedioxyamphetamine () was prepared by essentially the same procedure. The above 3-methoxy-4,5-dihydroxybenzaldehyde with trimethylene bromide gave 3-methoxy-4,5-trimethylenedioxybenzaldehyde, white solids, with a malononitrile derivative with a mp of 134–135 °C; the aldehyde with nitroethane gave the nitropropene with a mp of 86–87 °C; and this with LAH gave MTDA as the hydrochloride (mp 160–161 °C) again isolated first as the picrate. It had been tasted at up to an 8 milligram dosage (no activity, but none expected) before being abandoned. And, an initial effort was made to synthesize a five-member ring (methylenedioxy) with a methyl sticking out from it. This got as far as the aldehyde stage. The reaction between 3,4-dihydroxy-5-methoxybenzaldehyde and 1,1-dibromoethane in acetone containing anhydrous potassium carbonate gave a minuscule amount of a product that was a two-component mixture. This was resolved by dozens of separate injections into a preparatory gas chromatography system, allowing the isolation of the second of the two components in a quantity sufficient to demonstrate (by NMR spectroscopy) that it was the desired 3-methoxy-4,5-ethylidinedioxybenzaldehyde. Starting with the pre-prepared dipotassium salt or the lead salt of the catecholaldehyde gave nothing. With no activity being found with MEDA, all was abandoned.
There are some comments made under for successful chemistry (using a different approach) along these lines when there is no methoxyl group present. These are the compounds and . But the pharmacology was still not that exciting.
13 May 2016 · Creative Commons BY-NC-SA ·

About PiHKAL · info

This version of Book II of PiHKAL is based on the Erowid online version, originally transcribed by Simson Garfinkle and converted into HTML by Lamont Granquist. I drew also on “Tyrone Slothrop’s” (Unfinished) Review of PIHKAL to enumerate the many analogues mentioned in PiHKAL but not described at length. Many, many others have since been added.
I have tried here to expunge any artifacts introduced by the earlier transcriptions and restore the typographic niceties found in the printed edition. I’ve also made minor changes to some chemical names in line with current nomenclature practice. Typically the change is little more than expanding a prefix or setting it in italics. The history page has further details.

Cautionary note

“At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings.
“No one who is lacking legal authorization should attempt the synthesis of any of the compounds described in these files, with the intent to give them to man. To do so is to risk legal action which might lead to the tragic ruination of a life. It should also be noted that any person anywhere who experiments on himself, or on another human being, with any of the drugs described herein, without being familiar with that drug’s action and aware of the physical and/or mental disturbance or harm it might cause, is acting irresponsibly and immorally, whether or not he is doing so within the bounds of the law.”
Alexander T. Shulgin

Copyright notice

The copyright for Book I of PiHKAL has been reserved in all forms and it may not be distributed. Book II of PiHKAL may be distributed for non-commercial reproduction provided that the introductory information, copyright notice, cautionary notice and ordering information remain attached.

Ordering information

PiHKAL is the extraordinary record of the authors’ years exploring the chemistry and transformational power of phenethylamines. This book belongs in the library of anyone seeking a rational, enlightened and candid perspective on psychedelic drugs.
Though Sasha and Ann have put Book II of PiHKAL in the public domain, available to anyone, I strongly encourage you to buy a copy. We owe them — and there’s still nothing quite like holding a real book in your hands.
PiHKAL (ISBN 0-9630096-0-5) is available for US$24.50 (plus $10 domestic first-class shipping) from Transform Press.
Transform Press,
Box 13675
Berkeley, CA 94701

510 · 934 · 4930 (voice)
510 · 934 · 5999 (fax)