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Exploring 2C-TFM. To explore a different substance…

Names

2C-TFM
2C-CF₃
4-Trifuouromethyl-2,5-dimethoxyphenethylamine

IUPAC name

2-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]ethan-1-amine

ID 2040 · Formula C₁₁H₁₄F₃NO₂ · Molecular weight 249.23

InChI InChI=1S/C11H14F3NO2/c1-16-9-6-8(11(12,13)14)10(17-2)5-7(9)3-4-15/h5-6H,3-4,15H2,1-2H3

InChI Key LYXGNMLWYONZID-UHFFFAOYSA-N This stereoisomer Any stereoisomer

SMILES NCCc1cc(OC)c(cc1OC)C(F)(F)F

ChemSpider 8575233
PubChem 10399795
Wikidata Q3014225
Wikipedia 2C-TFM
Wikipedia, see also 2C (psychedelics)
Project Response 2C-TFM (1373-15)
bluelight.org The Big & Dandy 2C-TFM Thread

Shulgin Index #28 2C-TFM · Table 5Page 343Row 1

Phenethylamine: Von der Strucktur zur Funktion 2C-TFM: 8.5 (41) 768, 769, 771, 810, 823, 841

Braden, MR. Towards a biophysical understanding of hallucinogen action. Ph. D. Thesis, Purdue University, West Lafayette, IN, 1 Jan 2007. 8.4 MB. #2C-TFM

Nichols, DE; Frescas, SP; Marona-Lewicka, D; Huang, X; Roth, BL; Gudelsky, GA; Nash, JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A potent serotonin 5-HT_2A/2C agonist. J. Med. Chem., 1 Dec 1994, 37 (25), 4346–4351. 873 kB. https://doi.org/10.1021/jm00051a011

Trachsel, D. Fluorine in psychedelic phenethylamines. Drug Test. Anal., 1 Jul 2012, 4 (7-8), 577-590. 1.0 MB. https://doi.org/10.1002/dta.413

Parrish, JC. Toward a molecular understanding of hallucinogen action. Ph. D. Thesis, Purdue University, West Lafayette, IN, 1 Jan 2006. 5.5 MB.

Parrish, JC; Braden, MR; Gundy, E; Nichols, DE. Differential phospholipase C activation by phenylalkylamine serotonin 5-HT_2A receptor agonists. J. Neurochem., 1 Dec 2005, 95 (6), 1575–1584. 301 kB. https://doi.org/10.1111/j.1471-4159.2005.03477.x

Leth-Petersen, S; Bundgaard, C; Hansen, M; Carnerup, MA; Kehler, J; Kristensen, JL. Correlating the metabolic stability of psychedelic 5-HT_2A agonists with anecdotal reports of human oral bioavailability. Neurochem. Res., 12 Feb 2014, 39 (10), 2018-2023. 625 kB. https://doi.org/10.1007/s11064-014-1253-y

EMCDDA. New drugs in Europe, 2015, European Monitoring Centre for Drugs and Drug Addiction, Lisbon, 1 May 2016. 1.0 MB. #33

Monte, AP; Marona-Lewicka, D; Parker, MA; Wainscott, DB; Nelson, DL; Nichols, DE. Dihydrobenzofuran analogues of hallucinogens. 3. 1 Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. J. Med. Chem., 1 Jan 1996, 39 (15), 2953–2961. 290 kB. https://doi.org/10.1021/jm960199j #2c

Monte, AP. Structure-activity relationships of hallucinogens: Design, synthesis, and pharmacological evaluation of a series of conformationally restricted phenethylamines. Ph. D. Thesis, Purdue University, West Lafayette, IN, 1 Aug 1995. 10.7 MB. #2C-TFM MS,NMR

Fenderson5555. Trifluoromethylated phenethylamines. , 17 May 2021. . Fenderson5555 23.7 MB. #2C-CF₃

10014

10087

10131

DTFM

β-MeO-5H-2C-TFM

7 Dec 2019 · · Isomer Design