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Names

JWH-250
2MeO-BZ-PIMO

IUPAC name

2-(2-Methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one

ID 4317 · Formula C₂₂H₂₅NO₂ · Molecular weight 335.439

Tags Cannabinoid

InChI InChI=1S/C22H25NO2/c1-3-4-9-14-23-16-19(18-11-6-7-12-20(18)23)21(24)15-17-10-5-8-13-22(17)25-2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3

InChI Key FFLSJIQJQKDDCM-UHFFFAOYSA-N This stereoisomer Any stereoisomer

SMILES CCCCCn1cc(c2c1cccc2)C(=O)Cc1ccccc1OC

ChemSpider 23256117
PubChem 44397540
Wikidata Q4041747
Wikipedia JWH-250
Project Response JWH-250 (1491-16)
swgdrug.org JWH-250

EMCDDA. New drugs in Europe, 2011, European Monitoring Centre for Drugs and Drug Addiction, Lisbon, 1 Apr 2012. 401 kB.

Gwak, S; Arroyo-Mora, LE; Almirall, JR. Qualitative analysis of seized synthetic cannabinoids and synthetic cathinones by gas chromatography triple quadrupole tandem mass spectrometry Drug Test. Anal., 1 Feb 2015, 7 (2), 121-130. 1.1 MB. https://doi.org/10.1002/dta.1667 #13 GC,MS

Kneisel, S; Auwärter, V; Kempf, J. Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometry Drug Test. Anal., 1 Aug 2013, 5 (8), 657-669. 285 kB. https://doi.org/10.1002/dta.1429

Montenarh, D; Hopf, M; Warth, S; Maurer, HH; Schmidt, P; Ewald, AH. A simple extraction and LC-MS/MS approach for the screening and identification of over 100 analytes in eight different matrices: Detection of 130 analytes in eight biosamples using only one LC-MS/MS method Drug Test. Anal., 1 Mar 2015, 7 (3), 214-240. 593 kB. https://doi.org/10.1002/dta.1657 LC,MS

Banister, SD; Connor, M. The chemistry and pharmacology of synthetic cannabinoid receptor agonists as new psychoactive substances: Origins In New Psychoactive Substances: Pharmacology, Clinical, Forensic and Analytical Toxicology; Maurer, HH; Brandt, SD, Eds., Springer, Berlin, Heidelberg, 1 Jan 2018; pp 165-190. 906 kB. https://doi.org/10.1007/164_2018_143 #46

Adamowicz, P; Zuba, D. Discrimination among designer drug isomers by chromatographic and spectrometric methods In Chromatographic Techniques in the Forensic Analysis of Designer Drugs; Kowalska, T; Sajewicz, M; Sherma, J, Eds., CRC Press, Taylor & Francis Group, 1 Jan 2018; pp 211–232. 1.1 MB. LC,MS,IR,UV

Abbate, V; Schwenk, M; Presley, BC; Uchiyama, N. The ongoing challenge of novel psychoactive drugs of abuse. Part I. Synthetic cannabinoids (IUPAC Technical Report) Pure Appl. Chem., 28 Aug 2018, 90 (8), 1255–1282. 1.0 MB. https://doi.org/10.1515/pac-2017-0605 #4. JWH-250

Davidson, C; Opacka-Juffry, J; Arevalo-Martin, A; Garcia-Ovejero, D; Molina-Holgado, E; Molina-Holgado, F. Spicing up pharmacology: A review of synthetic cannabinoids from structure to adverse events In Adv. Pharmacol.; , Elsevier, 1 Jan 2017; pp 135–168. 458 kB. https://doi.org/10.1016/bs.apha.2017.05.001 #JWH-250

EMCDDA. New drugs in Europe, 2009, European Monitoring Centre for Drugs and Drug Addiction, Lisbon, 1 May 2010. 321 kB. #16

Wilkinson, SM; Banister, SD; Kassiou, M. Bioisosteric fluorine in the clandestine design of synthetic cannabinoids Aust. J. Chem., 10 Feb 2015, 68 (1), 4–8. 451 kB. https://doi.org/10.1071/CH14198 #15

Kraemer, M; Boehmer, A; Madea, B; Maas, A. Death cases involving certain new psychoactive substances: A review of the literature Forensic Sci. Int., 1 May 2019, 298, 186–267. 6.7 MB. https://doi.org/10.1016/j.forsciint.2019.02.021 #JWH-250

Meyers-Riggs, B. JWH-018 replacements countyourculture, countyourculture: rational exploration of the underground, 6 Dec 2010. #JWH-250

Meyers-Riggs, B. Phenylacetylindoles countyourculture, countyourculture: rational exploration of the underground, 8 Feb 2011. #JWH-250

Wouters, E; Walraed, J; Robertson, MJ; Meyrath, M; Szpakowska, M; Chevigné, A; Skiniotis, G; Stove, C. Assessment of biased agonism among distinct synthetic cannabinoid receptor agonist scaffolds ACS Pharmacol. Transl. Sci., 10 Apr 2020, 3 (2), 285–295. 2.0 MB. https://doi.org/10.1021/acsptsci.9b00069 #6

Harris, D; Hokanson, S; Miller, V. GC-MS Differentiation of three synthetic cannabinoid positional isomers: JWH-250, JWH-302, and JWH-201 JCLIC, 1 Oct 2011, 21 (4), 23-32. 1.5 MB. GC,MS

Spangler, MR; Benne, A. Synthetic cannabinoid isomer differentiation JCLIC, 1 Oct 2011, 21 (4), 17-22. 895 kB. MS

Hasegawa, T; Takahashi, K; Saijo, M; Fukiwake, T; Motoki, Y. Current situation and issues for analyzing illegal drug products Yakugaku Zasshi, 1 Jan 2013, 133 (1), 7–11. 396 kB. https://doi.org/10.1248/yakushi.12-00247-2 #JWH-250 GC,MS

Worob, A; Wenthur, C. DARK classics in chemical neuroscience: Synthetic cannabinoids (Spice/K2) ACS Chem. Neurosci., 2 Dec 2020, 11 (23), 3881–3892. 1.5 MB. https://doi.org/10.1021/acschemneuro.9b00586 #13

Andrews, R; Jorge, R; Christie, R; Gallegos, A. From JWH‐018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day Drug Test. Anal., 1 Apr 2023, 15 (4), 378–387. 1.2 MB. https://doi.org/10.1002/dta.3422 #JWH-250

JWH-201

3MeO-BZ-PIMO · JWH-302

4′-Phenyl-CPT

RTI-120

11851

25D-NM1Nap

MEPEA-NM1Nap

7 Dec 2019 · · Isomer Design