Schedule II [21 CFR 1308.12]
Source: Shulgin, Alexander T. Controlled Substances: Chemical & Legal Guide to Federal Drugs Laws (2nd edition). Ronin Publishing Inc., Berkeley, 1992
Source: DEA Office of Diversion Control: Section 1308: Schedules of Controlled Substances
(b)
Substances, vegetable origin or chemical synthesis. Unless specifically excepted or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin, or independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis:
(1)
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, thebaine-derived butorphanol, dextrorphan, nalbuphine, nalmefene, naloxegol, naloxone, and naltrexone, and their respective salts, but including the following:
Effective 23 Jan 2015, 80 FR 3468 replacement for:
On 29 Oct 2014, 79 FR 64349 proposed replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, thebaine-derived butorphanol, dextrorphan, nalbuphine, nalmefene, naloxone, and naltrexone, and their respective salts, but including the following:
Effective 14 Jul 1992, 57 FR 31126 replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, dextrorphan, nalbuphine, nalmefene, naloxone, and naltrexone, and their respective salts, but including the following:
Effective 4 Nov 1985, 50 FR 45815 replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, dextrorphan, nalbuphine, naloxone, and naltrexone, and their respective salts, but including the following:
Effective 1 Oct 1976, 41 FR 43401 replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium and opiate, excluding naloxone, naltrexone, and apomorphine, and their respective salts, but including the following:
Effective 28 Jun 1976, 41 FR 26568 replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding naloxone and its salts, and excluding naltrexone and its salts, but including the following:
Effective 6 Mar 1975, 40 FR 10455 replacement for:
On 9 Dec 1974, 39 FR 42918 proposed replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding naloxone and its salts, but including the following:
Effective 24 Dec 1974, 39 FR 44392 replacement for:
On 10 Jul 1974, 39 FR 25327 proposed replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding naloxone hydrochloride, but including the following:
Effective 29 Sep 1971, 36 FR 19116 replacement for:
On 19 Aug 1971, 36 FR 16119 proposed replacement for:
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate.
Effective 24 Sep 2007, 72 FR 54208 resequenced items (i) through (xviii) below
Effective 28 Jun 1976, 41 FR 26568 revoked (and renumbered subsequent entries):
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
9030
Apomorphine
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(i)
9050
Effective 17 Nov 2000, 65 FR 69442 added:
(ii)
9334
Dihydroetorphine
UK: MDA Part I Class A Section 1(a) Dihydroetorphine
UN: Narcotics Part 1 Section 1 Dihydroetorphine
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(iii)
9190
Ethylmorphine
CA: CDSA Schedule I Section 1 Subsection 13 Ethylmorphine
UK: MDA Part II Class B Section 1(a) Ethylmorphine
UN: Narcotics Part 1 Section 2 Ethylmorphine and Part 2 Section 1 Ethylmorphine
See also CSA Schedule III Section e Subsection 1 Item iv Ethylmorphine and Schedule V Section c Subsection 3 Ethylmorphine
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(v)
9640
Granulated opium
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(vi)
9193
Hydrocodone
CA: CDSA Schedule I Section 1 Subsection 15 Hydrocodone
UK: MDA Part I Class A Section 1(a) Hydrocodone
UN: Narcotics Part 1 Section 1 Hydrocodone
⇒
PubChem: 5284569; ChemSpider: 4447623; Drugs Forum: Hydrocodone; Erowid: Hydrocodone; Wikipedia: Hydrocodone
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(vii)
9150
Hydromorphone
CA: CDSA Schedule I Section 1 Subsection 17 Hydromorphone
UK: MDA Part I Class A Section 1(a) Hydromorphone
UN: Narcotics Part 1 Section 1 Hydromorphone
⇒
PubChem: 5284570; ChemSpider: 4447624; Drugs Forum: Hydromorphone; Erowid: Hydromorphone; Wikipedia: Hydromorphone
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(ix)
9300
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(x)
9610
Opium extracts
(xi)
9620
Opium fluid
Effective 31 Dec 1969, replacement for:
On 19 Aug 1971, 36 FR 16119 proposed to add:
Opium fluid extracts
Effective 29 Sep 1971, 36 FR 19116 added:
Effective 10 Dec 2007, 72 FR 69618 changed the controlled substance code number of Oripavine to 9330 from 9335
Effective 24 Sep 2007, 72 FR 54208 added:
(xii)
9330
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(xiv)
9652
Oxymorphone
CA: CDSA Schedule I Section 1 Subsection 29 Oxymorphone
UK: MDA Part I Class A Section 1(a) Oxymorphone
UN: Narcotics Part 1 Section 1 Oxymorphone
⇒
PubChem: 5284604; ChemSpider: 4447650; Bluelight: Oxymorphone; Drugs Forum: Oxymorphone; Erowid: Oxymorphone; Wikipedia: OxymorphoneEffective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(xv)
9639
Powdered opium
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(xvi)
9600
Raw opium
See also CSA Schedule III Section e Subsection 1 Item i Opium, Item v Opium and Schedule V Section c Subsection 5 Opium
⇒
PubChem: 167253 202889 202890 17397953 17397584 3842991 202886 202888 413265 3730541; Drugs Forum: Opium; Wikipedia: Opium
Effective 29 Sep 1971, 36 FR 19116 added:
On 19 Aug 1971, 36 FR 16119 proposed to add:
(xviii)
9630
Tincture of opium
(3)
Opium poppy and Poppy straw
Cocaine
Ecgonine
(4)
Coca leaves (9040) and any salt, compound, derivative or preparation of coca leaves (including Cocaine (9041) and Ecgonine (9180) and their salts, isomers, derivatives and salts of isomers and derivatives), and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include:
Effective 11 Sep 2015, 80 FR 54715 replacement for:
On 3 Jun 2015, 80 FR 31521 proposed replacement for:
Coca leaves (9040) and any salt, compound, derivative or preparation of coca leaves (including Cocaine (9041) and Ecgonine (9180) and their salts, isomers, derivatives and salts of isomers and derivatives), and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include decocainized coca leaves or extraction of coca leaves, whhch[sic] extractions do not contain cocaine or ecgonine.
CA: CDSA Schedule I Section 2 Subsection 1 Coca leaves
UK: MDA Part I Class A Section 1(a) Coca leaf
UN: Narcotics Part 1 Section 1 Coca leaf
Effective 11 Sep 2015, 80 FR 54715 added:
On 3 Jun 2015, 80 FR 31521 proposed to add:
(i)
Decocainized Coca leaves or extraction of Coca leaves, which extractions do not contain Cocaine or Ecgonine; or
![3D rendering of [123I]Ioflupane](data:image/png;base64,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 "Click for a 3D rendering of [123I]Ioflupane")
Effective 11 Sep 2015, 80 FR 54715 added:
On 3 Jun 2015, 80 FR 31521 proposed to add:
(ii)
[123I]Ioflupane.
Effective 14 Feb 1975, 40 FR 6779 added:
On 20 Dec 1974, 39 FR 44033 proposed to add:
(5)
9670
Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy).
UK: MDA Part I Class A Section 1(a) Concentrate of poppy-straw
UN: Narcotics Part 1 Section 1 Concentrate of poppy straw
11 March 2016 · 
· Isomer Design
· Isomer Design