Misuse of Drugs Act
Part II Class B Drugs
Source: L. A. King, Forensic Chemistry of Substance Misuse: A Guide to Drug Control, RSC Publishing, Cambridge, 2009
3D rendering of [2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone
Effective 23 Dec 2009, S.I. 2009/3209 added:
1(c)
[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone
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PubChem: 5689; ChemSpider: 5487; Bluelight: WIN 55,212-2; Wikipedia: WIN 55,212-2
3D rendering of 3-Dimethylheptyl-11-hydroxyhexahydrocannabinol
Effective 23 Dec 2009, S.I. 2009/3209 added:
3-Dimethylheptyl-11-hydroxyhexahydrocannabinol [sic]
The chemical name provided by the legislation seems dodgy. The structure shown is based on an alternative name, HU 243, mentioned in the Advisory Council on the Misuse of Drugs (ACMD) Consideration of the major cannabinoid agonists. This document provides a great overview of the wealth of synthetic cannabinoid recepter agonists. Curiously, parts of the report are redacted, “…on the ground that its publication would not be in the public interest.” Would that be the same “public interest” that led to the sacking of Dr. David Nutt, head of the ACMD?

L.A. King calls this name “technically incorrect.” He is being diplomatic. The correct name, he says, is: 9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol. It’s pretty easy to see how mistakes like that happen.
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PubChem: 44208947; ChemSpider: 24818295
3D rendering of [9-Hydroxy-6-methyl-3-[5-phenylpentan-2-yl]oxy-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl] acetate
Effective 23 Dec 2009, S.I. 2009/3209 added:
[9-Hydroxy-6-methyl-3-[5-phenylpentan-2-yl]oxy-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl] acetate
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Wikipedia: Levonantradol
3D rendering of 9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Effective 23 Dec 2009, S.I. 2009/3209 added:
9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
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PubChem: 4193475; ChemSpider: 3404012; Wikipedia: HU-210
3D rendering of Nabilone
Effective 23 Dec 2009, S.I. 2009/3209 added:
Nabilone
CA: CDSA Schedule II Section 2 Subsection 1 Nabilone
US: CSA Schedule II Section f Subsection 1 Nabilone
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PubChem: 5284592 39860; ChemSpider: 4447641; Wikipedia: Nabilone
3D rendering of 3-(1-Naphthoyl)indole
3-(1-Naphthoyl)indole
3D rendering of 3-(2-Naphthoyl)indole
3-(2-Naphthoyl)indole
3D rendering of 1H-Indol-3-yl-(1-naphthyl)methane
1H-Indol-3-yl-(1-naphthyl)methane
3D rendering of 1H-Indol-3-yl-(2-naphthyl)methane
1H-Indol-3-yl-(2-naphthyl)methane
Any compound structurally derived from 3-(1-Naphthoyl)indole, 3-(2-Naphthoyl)indole, 1H-Indol-3-yl-(1-naphthyl)methane or 1H-Indol-3-yl-(2-naphthyl)methane by substitution at the nitrogen atom of the indole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Effective 26 Feb 2013, S.I. 2013/239 replacement for:
On 8 Jan 2013, S.I. 2013/239* proposed replacement for:
Effective 23 Dec 2009, S.I. 2009/3209 added:
Any compound structurally derived from 3-(1-Naphthoyl)indole or 1H-Indol-3-yl-(1-naphthyl)methane by substitution at the nitrogen atom of the indole ring by alkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Special thanks to Nick for alerting me I had overlooked 3-(2-Naphthoyl)indole earlier. I always appreciate it when a reader reports an error or omission. Many eyes…
I looked without success for a representative of 3-(2-Naphthoyl)indole. The ACMD report has this telling rationale:
“In structures containing naphthoyl and adamantoyl groups, positional isomers may also be exploited and, as identification of a particular positional isomer could impose an unnecessary burden on forensic providers, we propose broadening the definitions of controlled compounds of these types to include all possible structures.”
It seems banning an infinite number of substances with totally unknown pharmacology is the price paid to avoid overburdening forensic providers. One hopes by this whim they have not forsaken, say, the next Viagra. Or something even more beneficial.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances controlled by the 3-(1-Naphthoyl)indole generic definition include: JWH-004, JWH-007, JWH-009, JWH-015, JWH-016, JWH-018, JWH-019, JWH-020, JWH-046, JWH-047, JWH-048, JWH-049, JWH-050, JWH-070, JWH-071, JWH-072, JWH-073, JWH-076, JWH-079, JWH-080, JWH-081, JWH-082, JWH-094, JWH-096, JWH-098, JWH-116, JWH-120, JWH-122, JWH-148, JWH-149, JWH-180, JWH-181, JWH-182, JWH-189, JWH-193, JWH-200, JWH-210, JWH-211, JWH-212, JWH-213, JWH-234, JWH-235, JWH-236, JWH-239, JWH-240, JWH-241, JWH-242, JWH-262, JWH-386, JWH-387, JWH-394, JWH-395, JWH-397, JWH-398, JWH-399, JWH-400, JWH-412, JWH-413, JWH-414, JWH-415, AM-1220 and MAM-2201.
Substances controlled by the 1H-Indol-3-yl-(1-naphthyl)methane generic definition include: JWH-175, JWH-184, JWH-185, JWH-192, JWH-194, JWH-195, JWH-196, JWH-197 and JWH-199.
Listed below are some examples of substances explicitly controlled in other jurisdictions that are members of the group implicitly controlled by this generic definition.
CA: CDSA Schedule II Section 2 Subsection 2 3-(1-Naphthoyl)indole
US: CSA Schedule I Section ii Item ii 3-(1-Naphthoyl)indole
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PubChem: 10355825; ChemSpider: 8531277
US: CSA Schedule I Section ii Item ii 3-(1-Naphthylmethane)indole
3D rendering of AM-2201
AM-2201
CA: CDSA Schedule II Section 2 Subsection 2 1-(5-Fluoropentyl)-3-(1-naphthoyl)indole
US: CSA Schedule I Section g Subsection 11 1-(5-Fluoropentyl)-3-(1-naphthoyl)indole
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PubChem: 53393997; ChemSpider: 24751884; Drugs Forum: AM-2201; Wikipedia: AM-2201
3D rendering of JWH-018
JWH-018
CA: CDSA Schedule II Section 2 Subsection 2 1-Pentyl-3-(1-naphthoyl)indole
US: CSA Schedule I Section g Subsection 3 1-Pentyl-3-(1-naphthoyl)indole
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PubChem: 10382701; ChemSpider: 8558143; Bluelight: JWH-018; Drugs Forum: JWH-018; Erowid: Spice Product; Wikipedia: JWH-018
3D rendering of JWH-073
JWH-073
CA: CDSA Schedule II Section 2 Subsection 2 1-Butyl-3-(1-naphthoyl)indole
US: CSA Schedule I Section g Subsection 4 1-Butyl-3-(1-naphthoyl)indole
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PubChem: 10471670; ChemSpider: 8647081; Bluelight: JWH-073; Erowid: Spice Product; Wikipedia: JWH-073
3D rendering of JWH-081
JWH-081
CA: CDSA Schedule II Section 2 Subsection 2 1-Butyl-3-(4-methoxy-1-naphthoyl)indole
US: CSA Schedule I Section g Subsection 8 1-Pentyl-3-[1-(4-methoxynaphthoyl)]indole
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PubChem: 10547208; ChemSpider: 8722599; Wikipedia: JWH-081
3D rendering of JWH-122
JWH-122
CA: CDSA Schedule II Section 2 Subsection 2 1-Pentyl-3-(4-methyl-1-naphthoyl)indole
US: CSA Schedule I Section g Subsection 9 1-Pentyl-3-(4-methyl-1-naphthoyl)indole
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PubChem: 44466638; ChemSpider: 24623066; Bluelight: JWH-122; Wikipedia: JWH-122
3D rendering of JWH-200
JWH-200
CA: CDSA Schedule II Section 2 Subsection 2 1-(2-Morpholin-4-ylethyl)-3-(1naphthoyl)indole
US: CSA Schedule I Section g Subsection 6 1-[2-(4-Morpholinyl)ethyl]-3-(1-naphthoyl)indole
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PubChem: 10045570; ChemSpider: 8221134; Drugs Forum: JWH-200; Erowid: Spice Product; Wikipedia: JWH-200
3D rendering of JWH-398
JWH-398
US: CSA Schedule I Section g Subsection 10 1-Pentyl-3-(4-chloro-1-naphthoyl)indole
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PubChem: 57458928; ChemSpider: 28647395; Drugs Forum: JWH-398; Wikipedia: JWH-398
3D rendering of 3-(1-Naphthoyl)pyrrole
3-(1-Naphthoyl)pyrrole
3D rendering of 3-(2-Naphthoyl)pyrrole
3-(2-Naphthoyl)pyrrole
Any compound structurally derived from 3-(1-Naphthoyl)pyrrole or 3-(2-Naphthoyl)pyrrole by substitution at the nitrogen atom of the pyrrole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the pyrrole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Effective 26 Feb 2013, S.I. 2013/239 replacement for:
On 8 Jan 2013, S.I. 2013/239* proposed replacement for:
Effective 23 Dec 2009, S.I. 2009/3209 added:
Any compound structurally derived from 3-(1-Naphthoyl)pyrrole by substitution at the nitrogen atom of the pyrrole ring by alkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the pyrrole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances controlled by the 3-(1-Naphthoyl)pyrrole generic definition include: JWH-030, JWH-145, JWH-146, JWH-147, JWH-150, JWH-156, JWH-243, JWH-244, JWH-245, JWH-246, JWH-292, JWH-293, JWH-307, JWH-308, JWH-346, JWH-348, JWH-363, JWH-364, JWH-365, JWH-367, JWH-368, JWH-369, JWH-370, JWH-371, JWH-373 and JWH-392.
CA: CDSA Schedule II Section 2 Subsection 3 3-(1-Naphthoyl)pyrrole
US: CSA Schedule I Section iii Item iii 3-(1-Naphthoyl)pyrrole
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PubChem: 15832251; ChemSpider: 10506445
3D rendering of 1-(1-Naphthylmethylene)indene
1-(1-Naphthylmethylene)indene
3D rendering of 1-(2-Naphthylmethylene)indene
1-(2-Naphthylmethylene)indene
3D rendering of 1-(2-Naphthylmethyl)indene
1-(2-Naphthylmethyl)indene
Any compound structurally derived from 1-(1-Naphthylmethylene)indene or 1-(2-Naphthylmethylene)indene by substitution at the 3-position of the indene ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indene ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Effective 26 Feb 2013, S.I. 2013/239 replacement for:
On 8 Jan 2013, S.I. 2013/239* proposed replacement for:
Effective 23 Dec 2009, S.I. 2009/3209 added:
Any compound structurally derived from 1-(1-Naphthylmethyl)indene[sic] by substitution at the 3-position of the indene ring by alkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indene ring to any extent and whether or not substituted in the naphthyl ring to any extent.
This amendment discretely corrects a significant error in the existing nomenclature which mistakes “methyl” for “methylene.” See structures at left.
I doubt many convictions will be overturned by this blunder, but it seems to me that the substances meant to be captured by this paragraph had, in fact, escaped and remained at large until the amendment came into force.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances controlled by the 1-(1-Naphthylmethylene)indene generic definition include: JWH-176.
US: CSA Schedule I Section iv Item iv 1-(1-Naphthylmethylene)indene
3D rendering of 3-Phenylacetylindole
Any compound structurally derived from 3-Phenylacetylindole by substitution at the nitrogen atom of the indole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the phenyl ring to any extent.
Effective 26 Feb 2013, S.I. 2013/239 replacement for:
On 8 Jan 2013, S.I. 2013/239* proposed replacement for:
Effective 23 Dec 2009, S.I. 2009/3209 added:
Any compound structurally derived from 3-Phenylacetylindole by substitution at the nitrogen atom of the indole ring with alkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the phenyl ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances controlled by the 3-Phenylacetylindole generic definition include: JWH-167, JWH-201, JWH-202, JWH-203, JWH-204, JWH-205, JWH-206, JWH-207, JWH-208, JWH-209, JWH-237, JWH-248, JWH-249, JWH-250, JWH-251, JWH-253, JWH-302, JWH-303, JWH-304, JWH-305, JWH-306, JWH-311, JWH-312, JWH-313, JWH-314, JWH-315, JWH-316, and Cannabipiperidiethanone.
CA: CDSA Schedule II Section 2 Subsection 4 3-Phenylacetylindole
US: CSA Schedule I Section v Item v 3-Phenylacetylindole
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PubChem: 266609; ChemSpider: 234313; Drugs Forum: Phenylacetylindoles
3D rendering of JWH-250
JWH-250
CA: CDSA Schedule II Section 2 Subsection 4 1-Pentyl-3-(2-methoxyphenylacetyl)indole
US: CSA Schedule I Section g Subsection 7 1-Pentyl-3-(2-methoxyphenylacetyl)indole
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PubChem: 44397540; ChemSpider: 23256117; Drugs Forum: JWH-250; Wikipedia: JWH-250
3D rendering of RCS-8
RCS-8
US: CSA Schedule I Section g Subsection 14 1-Cyclohexylethyl-3-(2-methoxyphenylacetyl)indole
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PubChem: 53394099; ChemSpider: 24751863; Bluelight: RCS-8; Drugs Forum: RCS-8; Wikipedia: RCS-8
3D rendering of 2-(3-Hydroxycyclohexyl)phenol
Effective 23 Dec 2009, S.I. 2009/3209 added:
Any compound structurally derived from 2-(3-Hydroxycyclohexyl)phenol by substitution at the 5-position of the phenolic ring by alkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the cyclohexyl ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances controlled by the 2-(3-Hydroxycyclohexyl)phenol generic definition include: CP-47-497, CP-55,940 and CP-56,667.
Listed below are some examples of substances explicitly controlled in other jurisdictions that are members of the group implicitly controlled by this generic definition.
US: CSA Schedule I Section i Item i 2-(3-Hydroxycyclohexyl)phenol
3D rendering of CP 47,497
CP 47,497
CA: CDSA Schedule II Section 2 Subsection 1 5-(1,1-Dimethylheptyl)-2-(3-hydroxycyclohexyl)phenol
US: CSA Schedule I Section g Subsection 1 5-(1,1-Dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol
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PubChem: 15942731; ChemSpider: 10205286; Drugs Forum: CP 47,497; Erowid: Spice Product; Wikipedia: CP 47,497
3D rendering of CP 47,497-C8
CP 47,497-C8 (Cannabicyclohexanol)
US: CSA Schedule I Section g Subsection 2 5-(1,1-Dimethyloctyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol
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PubChem: 23986041; Erowid: Spice Product; Wikipedia: Cannabicyclohexanol
3D rendering of 3-Benzoylindole
Effective 26 Feb 2013, S.I. 2013/239 added:
On 8 Jan 2013, S.I. 2013/239* proposed to add:
Any compound structurally derived from 3-Benzoylindole by substitution at the nitrogen atom of the indole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the phenyl ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances potentially controlled by the 3-Benzoylindole generic definition include: AM-679, AM-694, AM-2233, RCS-4, RCS-4 (C4), RCS-2 (2-isomer) and WIN 48,098 (Pravadoline)
CA: CDSA Schedule II Section 2 Subsection 5 3-Benzoylindole
US: CSA Schedule I Section v Item v 3-Benzoylindole
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PubChem: 84845; ChemSpider: 76537
3D rendering of AM-694
AM-694
US: CSA Schedule I Section g Subsection 12 1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole
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PubChem: 9889172; ChemSpider: 8064843; Drugs Forum: AM-694; Wikipedia: AM-694
3D rendering of RCS-4
RCS-4
US: CSA Schedule I Section g Subsection 13 1-Pentyl-3-[(4-methoxy)-benzoyl]indole
See also MDA Part II Class B Section 1(c) RCS-4
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PubChem: 56841530; ChemSpider: 24769418; Wikipedia: RCS-4; Wikipedia: RCS-4
3D rendering of RCS-4
RCS-4
US: CSA Schedule I Section g Subsection 13 1-Pentyl-3-[(4-methoxy)-benzoyl]indole
See also MDA Part II Class B Section 1(c) RCS-4
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PubChem: 56841530; ChemSpider: 24769418; Wikipedia: RCS-4; Wikipedia: RCS-4
3D rendering of 3-(1-Adamantoyl)indole
3-(1-Adamantoyl)indole
3D rendering of 3-(2-Adamantoyl)indole
3-(2-Adamantoyl)indole
Effective 26 Feb 2013, S.I. 2013/239 added:
On 8 Jan 2013, S.I. 2013/239* proposed to add:
Any compound structurally derived from 3-(1-Adamantoyl)indole or 3-(2-Adamantoyl)indole by substitution at the nitrogen atom of the indole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent and whether or not substituted in the adamantyl ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances potentially controlled by the 3-(1-Adamantoyl)indole generic definition include: AB-001 and AM-1248.
3D rendering of 3-(2,2,3,3-Tetramethylcyclopropylcarbonyl)indole
Effective 26 Feb 2013, S.I. 2013/239 added:
On 8 Jan 2013, S.I. 2013/239* proposed to add:
Any compound structurally derived from 3-(2,2,3,3-Tetramethylcyclopropylcarbonyl)indole by substitution at the nitrogen atom of the indole ring by alkyl, haloalkyl, alkenyl, cyanoalkyl, hydroxyalkyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl or 2-(4-morpholinyl)ethyl, whether or not further substituted in the indole ring to any extent.
Please note that there are many, many substances controlled by this paragraph that are not listed below, and the absence of a substance from this tally should not be taken as an indication of legality.
Substances potentially controlled by the 3-(2,2,3,3-Tetramethylcyclopropylcarbonyl)indole generic definition include: UR-144 and XLR-11.
3D rendering of UR-144
UR-144
CA: CDSA Schedule II Section 2 Subsection 6 (1-Pentyl-1H-indol-3-yl)(2,2,3,3- tetramethylcyclopropyl)-methanone
US: CSA Schedule I Section h Subsection 1 (1-Pentyl-1H-indol-3-yl)(2,2,3,3- tetramethylcyclopropyl)methanone
US: [proposed] CSA Schedule I Section g Subsection 16 (1-Pentyl-1H-indol-3-yl)(2,2,3,3- tetramethylcyclopropyl)methanone
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PubChem: 44626619; ChemSpider: 24634882; Bluelight: UR-144; Drugs Forum: UR-144; Wikipedia: UR-144
3D rendering of XLR11
XLR11
CA: CDSA Schedule II Section 2 Subsection 6 [1-(5-Fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
US: CSA Schedule I Section h Subsection 2 [1-(5-Fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone
US: [proposed] CSA Schedule I Section g Subsection 17 [1-(5-Fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone
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PubChem: 57501498; ChemSpider: 28537382; Bluelight: XLR11; Wikipedia: XLR-11 (drug)
11 March 2016 · Creative Commons BY-NC-SA ·